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RAMAN-11面扫描共聚焦拉曼系统

价    格:询价

产    地:日本更新时间:2019/7/15 13:41:34

品    牌:Nanophoton型    号:

状    态:正常点击量:3387

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济南鑫井医疗器械有限公司

联 系 人:母洁洁

电     话:0531-68629546

传     真:0531-68629559

等     级: (第 4年)

性     质:生产型,

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大阪大学风险企业NanoPhoton日前开发成功了可以彩色画面显示细胞等图像的激光扫描显微镜“RAMAN-11”。为了实现彩色显示运用了拉曼散射原理。这是全球首款基于拉曼散射的激光显微镜。分辨率为200nm。还可用于化合物半导体成膜过程中的失真检测等。    
  此次开发的激光扫描显微镜外形尺寸为720×700×800mm3。将从2005年9月开始接受订货,预计年内可销售10台。价格为3300万日元。激光器的寿命约5000小时,每天不间断使用的话可使用大约2年半。    

  激光显微镜包括发射显微镜和荧光显微镜等种类,但都仅能显示黑白图像。因此,此前需要使用有机色素给细胞着色,在基因操作时还需要给蛋白质染色。此次的开发品省去了上述麻烦,并可以对活细胞直接进行观察。    

  拉曼散射是光线照射物质时发生的一种现象,由于构成该物质的原子或分子发生固有振动,从而导致部分入射光波长发生极小的变化。这部分光线被成为拉曼散射光。如果能够准确地测量拉曼散射光,就可以根据波长的不同判断出物质的不同种类。不过,由于拉曼散射光极其微弱,所以很难检测,此前必须使用高性能的分光器才能进行检测。    

  为了开发此次的新产品,NanoPhoton在捕捉拉曼散射上做了大量努力。通过导入受光灵敏度较高的CCD型固体摄像元件、改进激光的扫描方法,成功实现了对拉曼散射的捕捉。CCD型固体摄像元件是美国的产品。此外,该公司还表示,由于激光的扫描方法正在申请专利,详细情况不便透露。    

 


产品参数

Raman microscope with ultra-high speed imaging capability

去NanoPhoton网站了解更多
下载NanoPhoton Raman-11产品资料

Features

  • Only a few minutes of acquisition time is required for Raman imaging.
     
  • Clear observation of fine structure by high spatial resolution of 0.3micro at x, y direction and 0.7micro at z direction.
     
  • Easy to learn and use software for all users.
     
  • High peak position accuracy (0.1 cm-1) enabling to measure the strain of the crystals.
     
  • One simple mouse click enabling to measure any location on the sample observed with CCD camera.
     
  • Small footprint by compact design.

Outline of RAMAN-11

RAMAN-11 is a next generation laser microscope observing an image of a sample with Raman scattering lights emitted from the molecules. Raman spectroscopy technique used for RAMAN-11 gives researchers the knowledge for the details of constituent elements of organelles or protein. By observing the Raman scattering lights emitted from the molecules of the living cells, distribution of the molecules can be imaged with the colors (wavelength) unique to those molecules without using the staining method.

When a molecule is illuminated with a monochromatic laser beam, a portion of the incident light is scattered with different color. This scattered light is called "Raman scattering" for the name of the discoverer. The Raman scattered light tells us about the molecular is specific to the molecule, like a fingerprint. In addition, the Raman scattered light from a crystal gives the lattice condition of the crystal such as distortion, defects and impurity, and therefore can be utilized for crystal analysis.

Due to the weakness of Raman scattered light, conventional micro Raman system took a long time for one point measurement and scanned the sample point by point to take images. The scanning speed of this method is very slow. RAMAN-11 has noteworthy capable to accelerate the imaging speed. Nanophoton's original technology of a flying spot scanning technique contributes 100 times faster image acquisition than conventional systems.

Examples of observation

面扫描共聚焦拉曼系统 面扫描共聚焦拉曼系统
A Raman image of fullerene(C60) schowing the intensity peak at 1470cm-1. The fullerene distribution generated on the substrate is observed. Raman observation image of a paint surface. With an unknown mixture of substances, the surface state and the anamorphism can be observed and analyzed at the microscopic scale.
面扫描共聚焦拉曼系统 面扫描共聚焦拉曼系统
Raman image of non-stained living cardiomyocytes. Raman peaks of lipid, protein, and nucleic acid are assigned to red, green and blue. Subcellular organelles and bio-molecules are observed. Phase contrast image(left) and Raman Image(center) of a white blood cell capturing foreign body.

 

 

 

NanoPhoton 三维扫描共聚焦拉曼系统

三维扫描共聚焦拉曼系统

Nonophoton's Laser Raman Microscope took a large step as RAMANplus. The RAMANplus has a built-in video rate confocal reflection system that acquires the three-dimensional surface profile very fast in advance of Raman measurenment. After the Raman measurement, the RAMANplus automatically appends the Raman chemical information to the three-dimensional profile.

去NanoPhoton网站了解更多
下载NanoPhoton Ramanplus产品资料

Features

  • Quick measurement of three-dimensional surface profile
     
  • Quick search of interesting points in bumpy samples
     
  • Ultra-fast and high-definition Raman imaging
    Easy link of chemical information to 3D-surface profile
     

Technologies

  • Video-rate confocal reflection microscopy
     
  • Parallel detection system of Raman spectra
    Laser beam scanning system
     

Observation example of Diamond file

三维扫描共聚焦拉曼系统

The reflected light confocal observation gives the precise extended focus reflected image (grey color). The Raman observation gives the data of the crystal quality. These data are acquired and overlaid automatically.

Green: High quality diamond
Yellow: Low quality diamond




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