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Tocris 特色抑制剂产品

价    格:询价

产    地:英国更新时间:2019/7/15 13:41:34

品    牌:Tocris型    号:

状    态:正常点击量:2174

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Tocris bioscience是位于英国布里斯托尔(Bristol)的高品质试剂提供商,共有2000多种产品,主要集中在神经科学和信号传导领域,产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等,主要产品包括GPCR ligands,神经传递素,离子通道调控剂,信号通路抑制剂等,这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者,其生产的影响神经系统的化学物质被多次引用,这些物质很多都来自Jeff WatkinsTocris 的创立人)在Bristol大学原创性的研究工作。

 Tocris 产品特点:

Unique range:广泛收集来自药物研究公司和大学的正式许可的化合物

Regularly first to market:新颖的独特的产品

Highest standards of product quality:市场上纯度最高的产品,一般大于99%

Expert service:提供专家大发3d服务

Excellent value:质量好价格中等

 主要为激酶、脱氢酶、受体和信号通路的抑制剂,欢迎大家多多选购。

货号

产品名称

规格

目录价(RMB

活动价(RMB

生物学活性

2999

RWJ 67657

10 mg

2579

1548

Selective p38α and p38β inhibitor (IC50 values are 1 and 11 μM respectively) that displays no activity at p38γ, p38δ and a range of other kinases. Potently inhibits TNF-α and IL-1β release (IC50 values are 3 and 11 nM respectively) and suppresses HIV-1 replication in T-cells in vitro. Displays cardioprotective and anti-inflammatory activity in vivo. Orally active.

2999

RWJ 67657

50 mg 

11396

6838

3291

PF 915275

10 mg

2104

1262

Potent and selective 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor (Ki = 2.3 nM) that displays little activity at 11βHSD2 (1.5% inhibition at 10 μM). Inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro (EC50 = 15 nM) and has antidiabetic activity in vivo. Orally active.

3291

PF 915275

50 mg 

9073

5444

3304

SU 16f

10 mg

2579

1548

Potent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 = 0.11 μM).

3304

SU 16f

50 mg 

11396

6838

3341

JK 184

10 mg

2287

1372

Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro.

3341

JK 184

50 mg 

9951

5971

   资料列示如下:

名称

简介

Ion Channels: Calcium or Potassium or Sodium

介绍了Tocris与钙\\钠离子通道相关的开启剂、激活剂、抑制剂、阻断剂等

Pain

介绍了Tocris与疼痛感觉相关的受体、酶、离子通道等的抵抗剂、抑制剂、阻断剂等

Cell CycleMitosis or G1,G2 and S

介绍了Tocris与细胞周期有丝分裂相关的微管、激酶等的抑制剂等

MAPK or Cytokine Signalling

介绍了TocrisMAPK/细胞因子信号通路相关的多种激酶等的抑制剂等

Angiogenesis

介绍了Tocris与血管生成相关的受体、酶、激酶、信号通路等的抑制剂、激活剂等

Apoptosis

介绍了Tocris与凋亡相关的抑制剂、诱导剂等

PPAR Ligands

介绍了TocrisPPAR相关的抵抗剂、抑制剂等

Growth Factor Receptors/ Opioid Receptors/ GABA/ Dopaminergics/ Adrenergics/ Serotonergics/ AMPK/ Adenosine/ Endocrinology/ Kinase research……





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